Holding on through DNA Replication: Histone Modification or Modifier?
نویسندگان
چکیده
Histone methylation is widely believed to contribute to epigenetic inheritance by persevering through DNA replication and subsequently templating methylation of daughter chromosome regions. However, a report in this issue (Petruk et al.) suggests that chromatin association of the methytransferase complexes themselves persists through replication and re-establishes histone methylation.
منابع مشابه
Chromatin dynamics during DNA replication.
Chromatin is composed of DNA and histones, which provide a unified platform for regulating DNA-related processes, mostly through their post-translational modification. During DNA replication, histone arrangement is perturbed, first to allow progression of DNA polymerase and then during repackaging of the replicated DNA. To study how DNA replication influences the pattern of histone modification...
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ورودعنوان ژورنال:
- Cell
دوره 150 شماره
صفحات -
تاریخ انتشار 2012